p300-mediated acetylation of the Notch effector transcription factor Maml-1 recruits NACK to initiate Notch-dependent transcription
نویسندگان
چکیده
Ke Jin, Wen Zhou, Xiaoqing Han, Zhiqiang Wang, Bin Li, Shawn Jeffries, Wensi Tao, David J. Robbins and Anthony J. Capobianco Molecular Oncology Program, Division of Surgical Oncology, Dewitt Daughtry Family Department of Surgery, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida. Department of Molecular Genetics, Biochemistry and Microbiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio. Current affiliation AbbVie Inc, North Chicago, IL. Dr. Nasser Ibrahim Al-Rashid Orbital Vision Research Center, Miller School of Medicine, University of Miami, Miami, Florida. Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida. Running title: p300 mediates NACK recruitment to the Notch complex
منابع مشابه
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.
Signaling through the Notch pathway activates the proteolytic release of the Notch intracellular domain (ICD), a dedicated transcriptional coactivator of CSL enhancer-binding proteins. Here we show that chromatin-dependent transactivation by the recombinant Notch ICD-CBF1 enhancer complex in vitro requires an additional coactivator, Mastermind (MAM). MAM provides two activation domains necessar...
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The Notch signaling is an evolutionary conserved pathway enabling short range cell-cell interactions, crucial for diverse developmental and physiological processes during embryonic and adult life. The Mastermind-like (MAML) family of transcriptional coactivator proteins has been shown to play an essential role in regulation of Notch-mediated transcription. Formation of DNA-bound ternary CSLNotc...
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The Notch signaling pathway governs many distinct cellular processes by regulating transcriptional programs. The transcriptional response initiated by Notch is highly cell context dependent, indicating that multiple factors influence Notch target gene selection and activity. However, the mechanism by which Notch drives target gene transcription is not well understood. Herein, we identify and ch...
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The Notch signaling pathway governs many distinct cellular processes by regulating transcriptional programs. The transcriptional response initiated by Notch is highly cell context dependent, indicating that multiple factors influence Notch target gene selection and activity. However, the mechanism by which Notch drives target gene transcription is not well understood. Herein, we identify and ch...
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